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pentobarbital will lower the extent or result of methylprednisolone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will decrease the level or effect of ketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.pentobarbital will reduce the level or effect of alo